Table 3.
Clinical and laboratory parameters
| Characteristics and month | CSA patients, mean ± SD | TAC patients, mean ± SD | P-value |
|---|---|---|---|
| Triglycerides, mg/dL | |||
| Baseline | 191.53±103.56 | 195.97±78.64 | ns |
| 6 | 164.76±88.70† | 170.67±82.26* | ns |
| 12 | 166.03±92.08† | 161.79±93.56* | ns |
| 24 | 163.19±135.50† | 158.76±84.17* | ns |
| Blood cholesterol, mg/dL | |||
| Baseline | 221.29±57.97 | 204.52±49.41 | ns |
| 6 | 190.20±38.21* | 180.13±37.03* | ns |
| 12 | 194.59±47.49* | 168.10±34.14* | 0.0002 |
| 24 | 193.72±46.61* | 178.14±35.50* | 0.0252 |
| HDL, mg/dL | |||
| Baseline | 60.13±23.61 | 62.28±19.42 | ns |
| 6 | 50.04±15.66* | 51.20±16.87* | ns |
| 12 | 50.50±18.13* | 49.14±18.11* | ns |
| 24 | 48.74±15.63* | 50.07±16.34* | ns |
| LDL, mg/dL | |||
| Baseline | 128.56±49.66 | 108.16±31.50 | 0.0068 |
| 6 | 109.11±29.47* | 94.71±31.76† | 0.0056 |
| 12 | 111.65±35.65* | 85.82±28.22* | <0.0001 |
| 24 | 114.04±30.51* | 95.77±31.42† | 0.0006 |
| Serum glucose, mg/dL | |||
| Baseline | 112.49±45.06 | 118.51±43.11 | ns |
| 6 | 100.91±20.56* | 116.99±51.96† | 0.0169 |
| 12 | 103.60±23.03† | 109.24±31.39† | ns |
| 24 | 109.15±30.15† | 114.00±37.04† | ns |
| ASAT, U/L | |||
| Baseline | 16.53±9.07 | 23.87±12.37 | 0.0003 |
| 6 | 15.21±7.71† | 24.49±11.04† | <0.0001 |
| 12 | 15.50±7.95† | 28.77±16.78* | <0.0001 |
| 24 | 16.39±8.29† | 29.83±32.79† | 0.0014 |
| ALAT, U/L | |||
| Baseline | 36.85±33.43 | 48.39±36.08 | 0.0444 |
| 6 | 15.63±10.84* | 26.04±20.75* | 0.0003 |
| 12 | 14.62±8.02* | 26.44±19.67* | <0.0001 |
| 24 | 17.62±13.55* | 24.33±15.24* | 0.0061 |
| GGT, U/L | |||
| Baseline | 104.96±90.20 | 273.93±242.54 | <0.0001 |
| 6 | 45.49±60.70* | 123.54±186.62* | 0.0013 |
| 12 | 32.69±34.99* | 122.28±199.35* | 0.0003 |
| 24 | 30.56±29.70* | 83.31±99.36* | <0.0001 |
| Serum bilirubin, mg/dL | |||
| Baseline | 1.58±1.16 | 0.88±0.62 | <0.0001 |
| 6 | 0.81±0.36* | 0.46±0.22* | <0.0001 |
| 12 | 0.81±0.37* | 0.54±0.27* | <0.0001 |
| 24 | 0.77±0.34* | 0.56±0.21* | <0.0001 |
| Hemoglobin, g/dL | |||
| Baseline | 11.28±1.18 | 11.21±1.10 | ns |
| 6 | 11.63±1.25* | 10.84±1.37* | 0.0004 |
| 12 | 12.03±1.39* | 11.68±1.61* | ns |
| 24 | 12.73±1.58* | 12.81±1.83* | ns |
| Thrombocytes, 1/nL | |||
| Baseline | 264.79±115.41 | 318.33±143.55 | 0.0134 |
| 6 | 238.88±71.73* | 230.41±74.87* | ns |
| 12 | 240.21±67.64* | 238.59±122.86* | ns |
| 24 | 244.29±66.47† | 215.83±67.27* | 0.0109 |
| Leukocytes, 1/nL | |||
| Baseline | 9.48±4.59 | 10.34±4.64 | ns |
| 6 | 5.33±2.11* | 4.63±1.99* | 0.0406 |
| 12 | 6.06±1.78* | 5.26±2.04* | 0.0131 |
| 24 | 6.67±1.97* | 6.26±2.03* | ns |
| Systolic blood pressure, mmHg | |||
| Baseline | 126.10±14.27 | 121.86±16.86 | ns |
| 6 | 127.40±15.91† | 122.72±15.13† | ns |
| 12 | 127.17±13.74† | 121.90±14.20† | 0.0230 |
| 24 | 126.15±15.77† | 121.06±14.44† | 0.0405 |
Notes:
*
P<0.05 vs baseline, statistically significant
†
P<0.05 vs baseline, ns.
Abbreviations: CSA, cyclosporine A; SD, standard deviation; TAC, tacrolimus; ns, not statistically significant; HDL, high-density lipoprotein; LDL, low-density lipoprotein; ASAT, aspartate aminotransferase; ALAT, alanine aminotransferase; GGT, gamma-glutamyltransferase.