Table 1.
Characteristics of enrolled subjects with a confirmed diagnosis of COPD (ie, post-bronchodilator FEV1/FVC <0.70) versus subjects not having COPD
| COPD (n=687) | No COPDa (n=3,362) | P-value | |
|---|---|---|---|
| Sex, male | 369 (54%) | 1,688 (50%) | 0.094 |
| Age | 63 (10.5) | 56 (11.8) | <0.001 |
| BMI | 26 (5.1) | 27 (5.1) | <0.001 |
| Pack-years | 40 (23.2) | 30 (21.9) | <0.001 |
| Symptoms | |||
| Cough | 501 (73%) | 2,389 (71%) | 0.324 |
| Dyspnea | 398 (58%) | 1,554 (46%) | <0.001 |
| Wheezing | 183 (27%) | 559 (17%) | <0.001 |
| Sputum | 281 (41%) | 963 (29%) | <0.001 |
| Recurrent RTI | 88 (13%) | 28 (10%) | 0.016 |
| MRC | 2 (0.8) | 1.7 (0.7) | <0.001 |
| Spirometry | |||
| FEV1 screeningb | 1.9 (0.69) | 2.8 (0.83) | <0.001 |
| FEV1 % predictedc | 68 (19.4) | 92 (18.2) | <0.001 |
Notes: Data are given as the mean ± standard deviation or number of subjects (%).
a
Subjects with FEV1/FVC ≥0.70 or post-bronchodilator ΔFEV1 <0.500 L
b
FEV1 at initial screening spirometry
c
FEV1 % predicted.
Abbreviations: BMI, body mass index; COPD, chronic obstructive pulmonary disease; FEV1, forced expiratory volume in one second; FVC, forced vital capacity; MRC, Medical Research Council dyspnea scale; RTI, respiratory tract infection.