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. 2015 Feb 24;9:1193–1208. doi: 10.2147/DDDT.S72127

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© 2015 Ahmadipour et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Western blot analysis of the Wnt/β-catenin self-renewal pathway in MCF7 cells treated with koenimbin. Koenimbin downregulated this pathway.

Notes: Koenimbin decreased protein expression levels of β-catenin and cyclin D1 in MCF7 cells (A). Koenimbin increased the phospho-β-catenin Ser33/Ser37/Thr41, whereas LiCl suppressed phosphorylation through inactivation of GSK3β (B). Koenimbin decreased the expression level of p-GSK3β, while the protein expression of total GSK3β was unchanged (C). Koenimbin decreased β-catenin and LiCl-induced GSK3β phosphorylation, while LiCl elevated the protein expression level of β-catenin through GSK3β phosphorylation (D). Each experiment was performed three times (n=3).

Abbreviation: GSK, glycogen synthase kinase.