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Role of the ToxR regulon in controlling cholera toxin (CTX) expression. The inner-membrane proteins TcpP and ToxR bind DNA at the toxT promoter, and activate transcription of toxT. ToxS and TcpH contribute to the function or stability of ToxR and TcpP, respectively. ToxT activates ctxAB and tcpA–F transcription. Figure modified from reference [47].
