Table 1.

Association of single nucleotide polymorphisms with incident atrial fibrillation in the Malmo Diet and Cancer Study

Locus	Gene	SNP	Modeled allele	Other allele	MAF‡	Risk estimate from literature (weight)	Ref	Risk estimate from MDC study
								Model 1		Model 2
								HR (95%CI)	P value	HR (95%CI)	P value
1q21	KCNN3	rs13376333	T	C	0.34	1.13 (0.12)	[22]	1.09 (1.02-1.16)	6.7×10−3	1.10 (1.03-1.17)	5.5×10−3
1q24	PRRX1	rs3903239	G	A	0.47	1.14 (0.13)	[23]	1.11 (1.04-1.18)	8.3×10−4	1.11 (1.05-1.19)	6.4×10−4
4q25	PITX2	rs10033464*	T	G	0.09	1.39 (0.33)	[18]	1.16 (1.05-1.29)	3.2×10−3	1.16 (1.04-1.29)	5.7×10−3
4q25	PITX2	rs2200733†	T	C	0.10	1.72 (0.54)	[18]	1.46 (1.34-1.60)	2.2×10−16	1.45 (1.32-1.59)	8.1×10−15
4q25	PITX2	rs17570669*	T	A	0.08	0.73 (−0.31)	[20]	0.76 (0.67-0.85)	8.7×10−6	0.76 (0.67-0.86)	2.4×10−5
4q25	PITX2	rs3853445*	C	T	0.27	0.86 (−0.15)	[20]	0.85 (0.80-0.92)	1.3×10−5	0.84 (0.78-0.90)	1.8×10−6
7q31	CAV1	rs3807989	A	G	0.41	0.9 (−0.11)	[23]	0.92 (0.86-0.98)	5.9×10−3	0.90 (0.85-0.96)	2.3×10−3
9q22	C9orf3	rs10821415	A	C	0.41	1.11 (0.10)	[23]	1.02 (0.96-1.08)	0.55	1.03 (0.96-1.09)	0.4
10q22	SYNPO2L	rs10824026	G	A	0.16	0.87 (−0.14)	[23]	0.85 (0.78-0.92)	1.4×10−4	0.83 (0.76-0.91)	6.4×10−5
14q23	SYNE2	rs1152591	A	G	0.49	1.13 (0.12)	[23]	1.02 (0.96-1.09)	0.48	1.03 (0.97-1.10)	0.35
15q24	HCN4	rs7164883	G	A	0.17	1.19 (0.17)	[23]	1.09 (1.00-1.17)	0.04	1.09 (1.01-1.18)	0.032
16q22	ZFHX3	rs2106261	T	C	0.18	1.24 (0.22)	[23]	1.10 (1.02-1.19)	0.016	1.10 (1.01-1.19)	0.025

Model 1: adjusted for age and sex

Model 2: adjusted for age, sex, BMI, systolic and diastolic blood pressure, use of antihypertensive medications, current smoking, prevalent diabetes, prevalent coronary heart disease, and prevalent heart failure.

^*Adjusted for rs2200733

^†Adjusted for rs10033464

^‡MAF is minor allele frequency in this study. This allele is also the minor allele among Utah residents with ancestry from northern and western Europe (CEU) reported by the International HapMap project. The minor allele is the modeled allele.