Table 3.
Atrial fibrillation and ischemic stroke event rates and risk estimates according to AF-GRS quintiles
| AF-GRS Quintile |
Ptrend | |||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 5 | |||
| Atrial fibrillation | ||||||
| N (Event) | 4,839 (292) | 4,868 (307) | 4,845 (367) | 4,890 (442) | 4,885 (527) | |
| Event rate (95%CI) | 4.33 (3.84 - 4.86) | 4.52 (4.02 - 5.05) | 5.44 (4.89 - 6.03) | 6.59 (5.98 - 7.23) | 7.90 (7.23 - 8.61) | |
| HR (95%CI) | Reference | 1.09 (0.93 - 1.28) | 1.30 (1.12 - 1.52) | 1.60 (1.38 - 1.86) | 2.00 (1.73 - 2.31) | 1.8×10−28 |
| P value (vs. Q1) | 0.3 | 7.7×10−4 | 4.7×10−10 | 2.7×10−21 | ||
| Ischemic stroke | ||||||
| N (Event) | 4,804 (254) | 4,831 (251) | 4,800 (237) | 4,857 (260) | 4,851 (296) | |
| Event rate (95%CI) | 3.80 (3.34 - 4.29) | 3.74 (3.29 - 4.24) | 3.53 (3.09 - 4.01) | 3.87 (3.41 - 4.37) | 4.41 (3.92 - 4.94) | |
| HR (95%CI) | Reference | 1.01 (0.85 - 1.21) | 0.95 (0.80 - 1.14) | 1.03 (0.87 - 1.23) | 1.23 (1.04 - 1.46) | 0.02 |
| P value (vs. Q1) | 0.9 | 0.6 | 0.7 | 0.015 | ||
Quintile boundaries: 1 GRS≤0.1453; 2 GRS>0.1453 and ≤0.3469; 3 GRS >0.3469 and ≤0.5284; 4 GRS>0.5284 and ≤0.7643; 5 GRS >0.7643.
Event rates are per 1000 person-years.
Hazard ratios from Cox proportional hazards models adjusted for age, sex, BMI, systolic and diastolic blood pressure, use of antihypertensive medications, current smoking, prevalent diabetes, prevalent coronary heart disease, and prevalent heart failure.