Table 1.
Candidate driver mutations affecting characteristics of ovarian cancer
| Type | Genomic position (hg19) | Base change | Gene | Amino acid change | Predicted as damaging† | COSMIC (ID) |
|---|---|---|---|---|---|---|
| Common | chr17:7578190 | T>C | TP53 | Y220C | 7/7 | COSM99720 |
| chr6:17781485 | C>T | KIF13A | G1198S | 6/7 | - | |
| chr14:25044511 | G>A | CTSG | R55* | N/A | - | |
| chr15:92459643 | T>C | SLCO3A1 | Y201H | 6/7 | - | |
| chr12:101880256 | G>A | SPIC | E152K | 2/7 | COSM458288 | |
| Shared (P1, M) | chr10:28905209 | T>G | WAC | L555* | N/A | - |
| chr14:24879362 | G>T | NYNRIN | G788* | N/A | - | |
| chr21:37710167 | G>T | MORC3 | G128V | 6/7 | - | |
| chr1:154184966 | C>G | C1orf43 | D159H | 6/7 | - | |
| chr4:154626187 | A>G | TLR2 | S710G | 6/7 | - | |
| chr12:52183202 | G>C | SCN8A | K1432N | 6/7 | - | |
| chr14:23886761 | G>C | MYH7 | S1435C | 6/6 | - | |
| chr1:11594572 | G>A | PTCHD2 | W1170* | N/A | - | |
| chr12:20799431 | C>A | PDE3A | N753K | 6/7 | - | |
| chr2:196545035 | G>T | SLC39A10 | G90V | 6/7 | - | |
| Cluster P1-specific | chr1:43317062 | T>G | ZNF691 | C176G | 6/7 | - |
| chr13:113893782 | G>T | CUL4A | D318Y | 6/7 | - | |
| chr6:117892084 | C>A | GOPC | G276V | 6/7 | - | |
| chr11:134090616 | C>A | NCAPD3 | W23C | 6/7 | - | |
| Cluster M- specific | chr1:206944347 | T>C | IL10 | M95V | 5/7 | - |
| chr2:242690697 | C>G | D2HGDH | S345C | 7/7 | - | |
| Cluster P2-specific | chr15:80866542 | C>G | ARNT2 | S457* | N/A | - |
| chr8:72211468 | C>G | EYA1 | D214H | 7/7 | - | |
| chr3:101371645 | T>G | ZBTB11 | H816P | 7/7 | - | |
| chr10:6528056 | A>T | PRKCQ | C281S | 7/7 | - |
†Predicted as damaging = (the number of algorithms predicting a damaging mutation)/(the number of available algorithms). The prediction algorithms and their cutoffs were described in the Methods.
*Stop codon.
N/A = not available.