Table 3.

Transplant Outcomes, Univariate Analyses

Variable	CNS relapse		Total Relapse		Overall Mortality
	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
Age, continuous variable	0.97 (0.94, 1.004)	0.08	0.99 (0.98, 1.002)	0.09	1.01 (1.001, 1.02)	0.03
Sex
Female	--------	--------	--------	--------	--------	--------
Male	0.69 (0.27, 1.73)	0.42	1.02 (0.72, 1.43)	0.92	1.12 (0.86, 1.44)	0.40
Lineage
B-cell	--------	--------	--------	--------	--------	--------
T-cell	0.83 (0.19, 3.59)	0.80	1.71 (1.10, 2.67)	0.02	1.09 (0.76, 1.59)	0.61
Cytogenetic risk group	*	*
Good			--------	--------	--------	--------
Intermediate			1.21 (0.55, 2.67)	0.64	0.83 (0.45, 1.53)	0.55
Poor			1.13 (0.78, 1.62)	0.52	0.87 (0.48, 1.58)	0.65
Pre CNS involvement	5.84 (2.33, 14.64)	0.0002	1.17 (0.73, 1.86)	0.52	1.33 (0.96, 1.85)	0.09
Disease status
CR1	--------	--------	--------	--------	--------	--------
CR2	1.47 (0.59, 3.69)	0.41	1.87 (1.34, 2.63)	0.0003	1.95 (1.52, 2.51)	<0.0001
Conditioning regimen
MA	--------	--------	--------	--------	--------	--------
Others	0.36 (0.05, 2.77)	0.33	1.20 (0.75, 1.91)	0.45	1.19 (0.83, 1.68)	0.34
Graft Source	*	*
Bone Marrow			--------	--------	--------	--------
Cord Blood			0.66 (0.31, 1.39)	0.27	2.33 (1.52, 3.57)	0.0001
Peripheral Blood			1.25 (0.84, 1.87)	0.28	1.22 (0.90, 1.66)	0.20
Allotype
HLA Matched-Related	--------	--------	--------	--------	--------	--------
HLA Matched Unrelated	0.50 (0.17, 1.43)	0.20	0.70 (0.48, 1.03)	0.07	0.88 (0.66, 1.18)	0.40
HLA Mismatched-Related	0.85 (0.10, 7.00)	0.89	0.67 (0.27, 1.64)	0.38	1.40 (0.78, 2.50)	0.25
HLA Mismatched Unrelated	0.20 (0.03, 1.54)	0.12	0.57 (0.34, 0.97)	0.04	1.53 (1.10, 2.14)	0.01
Post-HSCT CNS prophylaxis	3.88 (0.85, 17.61)	0.08	1.22 (0.82, 1.83)	0.32	0.47 (0.36, 0.61)	<0.0001
Post-HSCT IT prophylactic cycles
<4	--------	--------	--------	--------	--------	--------
≥4	2.54 (0.77, 8.41)	0.13	1.01 (0.68, 1.49)	0.98	0.45 (0.34, 0.60)	<0.0001