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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2014 Jul 24;90(2):376–384. doi: 10.1016/j.ijrobp.2014.03.049

Table 1.

Patient characteristics and summary of radiation treatment and metabolic volumes

Patient ID Age Sex Brain volume (mm3) RT volumes (mm3)
 Metabolic volumes (mm3)
 % of MTVCho outside of:
 % of MTVNAAoutside of:
GTV Edema CTV60 CTV46 MRSIQ MTVCho MTVNAA GTV Edema CTV60 CTV46 GTV Edema
T1* 40 M 1341 24 151 280 415 989 27 150 99.8 50.9 0.3 0.0 83.8 20.6
T2 53 M 1242 70 101 352 359 872 10 28 39.6 29.8 0.1 0.1 0.7 0.1
T3 60 F 1297 31 44 187 157 922 37 31 51.0 39.7 0.0 0.0 22.8 14.2
T4 60 M 1335 116 207 505 566 941 15 124 25.6 6.4 0.0 0.0 18.3 5.1
T5 31 F 1122 20 31 188 176 798 20 18 84.2 76.5 21.9 23.2 20.2 7.0
T6† 47 M 1398 118 118 429 367 1067 104 91 24.7 24.7 0.1 0.1 9.0 9.0
T7# 30 M 1268 12 156 266 410 907 161 185 92.8 25.1 15.6 3.2 93.4 22.3
T8 34 M 1406 31 187 350 590 1040 227 83 86.7 33.3 15.7 1.4 65.1 14.3
T9 50 M 1377 24 52 312 276 1023 12 44 91.8 90.8 7.4 12.7 52.5 27.2
T10 62 F 1188 43 91 310 347 893 16 68 54.3 46.6 21.3 20.8 39.4 8.1
T11 38 M 1239 100 255 483 533 881 21 153 47.2 11.0 0.0 0.3 39.3 11.9
T12 47 M 1439 61 89 409 396 1072 17 67 97.8 95.5 55.8 8.8 25.2 11.5
T13 69 M 1322 59 163 371 451 978 2 72 100 100 100 86.5 30.5 2.1
T14 66 M 1284 42 82 466 443 943 58 32 46.2 24.4 0.7 3.4 23.5 8.0
T15§ 41 F 1302 122 221 491 561 969 28 104 63.3 35.5 3.4 3.5 14.5 2.6
T16 38 M 1497 14 96 279 365 1133 3 8 45.2 0.0 0.0 0.0 66.8 14.4
T17 65 F 1079 75 96 280 296 768 35 33 64.3 57.3 10.4 17.0 9.9 6.1
T18 47 M 1564 161 222 589 551 1153 19 61 5.5 5.5 2.0 2.0 4.6 3.1
T19 50 F 1117 36 108 241 311 840 14 31 46.7 10.2 1.4 1.4 19.3 2.7
Median 47 - 1302 43 108 350 396 943 20 67 54.3 33.3 2.0 2.0 22.8 8.1
IQR 21 - 147 60 85 168 163 144.5 21.5 66 46.4 36.4 15.6 10.7 26.8 9.0

Abbreviations: Cho = choline; CTV46 = clinical target volume, receiving radiation dose of 46 Gy (CTV46 = edema + 2 cm); CTV60 = clinical target volume, receiving radiation dose of 60 Gy (CTV60 = GTV+2.5 cm); F = female; GTV = gross tumor volume; IQR = interquartile range (a measure of statistical dispersion, being equal to the difference between the upper [75th percentile] and lower [25th percentile] quartile); M = male; MRSI = magnetic resonance spectroscopic imaging; MRSIQ = volume of MRSI within the “quality mask”; MTV = metabolic tumor volume; MTVCho = MTV, based on Cho values above estimated threshold; MTVNAA = MTV, based on NAA values below estimated threshold; NAA = N-acetylaspartate; RT = radiation therapy.

#

Data from this patient are reviewed in detail in Figure 2.

*

Data from this patient are reviewed in detail in Figure 3.

†

Data from this patient are reviewed in detail in Figure 5.

§

Data from this patient are reviewed in detail in Figure 4.