Appendix Table 3. Adjusted Estimated Prevalence of Symptoms between 1998 and 2010 among Decedent Categories (Minimally Adjusted Models)a.
| % of Decedents (95% CIs)b | ||||||||
|---|---|---|---|---|---|---|---|---|
| Year of Death | ||||||||
| Category | Outcome | 1998 | 2000 | 2002 | 2004 | 2006 | 2008 | 2010 |
| Cancer | Moderate or severe pain | 58.4 (52.5, 64.4) |
59.5 (55.2, 63.8) |
60.6 (57.5, 63.8) |
61.7 (58.7, 64.8) |
62.8 (58.8, 66.8) |
63.9 (58.5, 69.2) |
65.0 (57.9, 72.1) |
| Any pain | 62.1 (56.3, 67.9) |
63.5 (59.3, 67.7) |
64.9 (61.9, 67.9) |
66.2 (63.6, 68.8) |
67.5 (64.3, 70.8) |
68.8 (64.4, 73.3) |
70.2 (64.3, 76.1) |
|
| Depression | 50.4 (45.7, 55.1) |
51.4 (47.8, 54.9) |
52.3 (49.5, 55.2) |
53.3 (50.4, 56.2) |
54.3 (50.6, 57.9) |
55.2 (50.3, 60.1) |
56.2 (49.9, 62.5) |
|
| Periodic confusion | 38.0 (33.3, 42.8) |
39.7 (36.1, 43.2) |
41.3 (38.6, 44.0) |
43.0 (40.4, 45.6) |
44.7 (41.3, 48.0) |
46.4 (41.8, 51.0) |
48.2 (42.1, 54.4) |
|
| Dyspnea | 52.6 (47.8, 57.5) |
53.0 (49.3, 56.8) |
53.5 (50.5, 56.5) |
53.9 (50.9, 56.9) |
54.3 (50.7, 58.0) |
54.8 (50.0, 59.5) |
55.2 (49.1, 61.4) |
|
| Incontinence | 44.3 (39.3, 49.4) |
43.6 (39.6, 47.5) |
42.9 (39.7, 46.1) |
42.1 (39.1, 45.2) |
41.4 (37.9, 44.9) |
40.7 (36.3, 45.1) |
39.9 (34.4, 45.5) |
|
| Severe fatigue | 77.0 (71.4, 82.5) |
77.4 (73.5, 81.3) |
77.8 (75.2, 80.4) |
78.3 (76.1, 80.4) |
78.7 (75.8, 81.6) |
79.1 (74.9, 83.3) |
79.6 (73.8, 85.3) |
|
| Anorexia | 77.0 (72.6, 81.5) |
78.2 (75.0, 81.4) |
79.3 (76.9, 81.7) |
80.3 (77.9, 82.7) |
81.3 (78.4, 84.3) |
82.3 (78.5, 86.1) |
83.3 (78.5, 88.1) |
|
| Frequent vomiting | 19.3 (14.4, 24.3) |
20.1 (16.2, 24.0) |
20.9 (17.9, 23.9) |
21.7 (19.2, 24.3) |
22.5 (19.8, 25.3) |
23.4 (19.7, 27.0) |
24.3 (19.3, 29.4) |
|
| CHF or chronic lung disease | Moderate or severe pain | 49.4 (45.0, 53.8) |
50.7 (47.5, 54.0) |
52.0 (49.6, 54.4) |
53.3 (51.0, 55.6) |
54.6 (51.5, 57.7) |
55.9 (51.7, 60.1) |
57.3 (51.7, 62.9) |
| Any pain | 54.4 (50.5, 58.4) |
56.5 (53.5, 59.5) |
58.6 (56.2, 60.9) |
60.6 (58.2, 63.0) |
62.6 (59.6, 65.6) |
64.6 (60.7, 68.4) |
66.6 (61.8, 71.5) |
|
| Depression | 50.5 (45.4, 55.6) |
52.6 (48.7, 56.6) |
54.8 (51.7, 57.8) |
56.9 (54.3, 59.4) |
58.9 (56.2, 61.7) |
61.0 (57.6, 64.4) |
63.1 (58.7, 67.6) |
|
| Periodic confusion | 46.9 (41.7, 52.1) |
48.2 (44.3, 52.1) |
49.5 (46.6, 52.4) |
50.7 (48.4, 53.1) |
52.0 (49.4, 54.6) |
53.3 (49.8, 56.8) |
54.7 (49.9, 59.4) |
|
| Dyspnea | 74.3 (69.8, 78.8) |
74.6 (71.2, 78.0) |
74.9 (72.4, 77.5) |
75.2 (73.2, 77.2) |
75.5 (73.3, 77.7) |
75.8 (73.0, 78.6) |
76.1 (72.3, 79.9) |
|
| Incontinence | 48.4 (43.1, 53.6) |
48.6 (44.7, 52.6) |
48.9 (46.0, 51.7) |
49.1 (46.9, 51.3) |
49.3 (46.9, 51.8) |
49.6 (46.1, 53.1) |
49.8 (45.0, 54.7) |
|
| Severe fatigue | 68.2 (64.0, 72.4) |
68.3 (65.1, 71.5) |
68.4 (66.0, 70.7) |
68.4 (66.5, 70.4) |
68.5 (66.2, 70.8) |
68.6 (65.5, 71.7) |
68.7 (64.4, 73.0) |
|
| Anorexia | 68.5 (63.6, 73.4) |
68.7 (64.9, 72.4) |
68.8 (65.9, 71.6) |
68.9 (66.6, 71.3) |
69.1 (66.6, 71.6) |
69.2 (65.9, 72.5) |
69.3 (65.0, 73.7) |
|
| Frequent vomiting | 12.0 (8.2, 15.7) |
11.3 (8.7, 14.0) |
10.7 (8.9, 12.5) |
10.1 (8.8, 11.4) |
9.5 (8.0, 11.1) |
9.0 (7.0, 11.1) |
8.5 (5.8, 11.2) |
|
| Frailty | Moderate or severe pain | 36.5 (29.9, 43.1) |
37.3 (32.3, 42.3) |
38.1 (34.4, 41.8) |
38.9 (35.7, 42.0) |
39.7 (35.9, 43.5) |
40.5 (35.3, 45.7) |
41.4 (34.3, 48.5) |
| Any pain | 42.7 (36.7, 48.6) |
43.9 (39.2, 48.7) |
45.2 (41.4, 49.0) |
46.5 (43.0, 50.0) |
47.8 (43.9, 51.7) |
49.1 (44.2, 54.0) |
50.5 (44.2, 56.8) |
|
| Depression | 42.6 (36.7, 48.6) |
45.3 (40.7, 49.9) |
47.9 (44.4, 51.4) |
50.6 (47.7, 53.5) |
53.2 (50.1, 56.4) |
55.9 (51.8, 60.0) |
58.7 (53.2, 64.2) |
|
| Periodic confusion | 69.3 (62.3, 76.3) |
72.0 (67.0, 77.0) |
74.5 (71.0, 78.1) |
76.9 (74.1, 79.8) |
79.2 (76.0, 82.3) |
81.2 (77.3, 85.1) |
83.3 (78.5, 88.1) |
|
| Dyspnea | 28.8 (22.4, 35.2) |
29.2 (24.3, 34.1) |
29.6 (26.1, 33.2) |
30.1 (27.4, 32.8) |
30.5 (27.6, 33.4) |
30.9 (27.0, 34.9) |
31.4 (25.8, 37.1) |
|
| Incontinence | 67.0 (59.9, 74.0) |
66.7 (61.1, 72.4) |
66.5 (62.0, 71.0) |
66.3 (62.5, 70.2) |
66.1 (62.1, 70.1) |
65.9 (61.0, 70.8) |
65.7 (59.4, 72.0) |
|
| Severe fatigue | 53.0 (46.4, 59.7) |
52.9 (48.1, 57.6) |
52.7 49.4, 56.0) |
52.5 (49.4, 55.5) |
52.3 (48.1, 56.4) |
52.1 (46.1, 58.0) |
51.9 (43.8, 60.0) |
|
| Anorexia | 68.0 (59.9, 76.1) |
67.3 (61.2, 73.5) |
66.7 (62.2, 71.1) |
66.0 (62.5, 69.5) |
65.3 (61.5, 69.2) |
64.7 (59.2, 70.1) |
63.9 (56.3, 71.6) |
|
| Frequent vomiting | 6.7 (3.6, 9.9) |
6.5 (4.2, 8.9) |
6.4 (4.6, 8.1) |
6.2 (4.5, 7.8) |
6.0 (4.1, 7.9) |
5.8 (3.3, 8.3) |
5.6 (2.5, 8.8) |
|
| Sudden death | Moderate or severe pain | 37.0 (29.6, 44.3) |
38.4 (32.9, 43.9) |
39.9 (36.0, 43.7) |
41.3 (38.4, 44.3) |
42.8 (39.3, 46.3) |
44.3 (39.2, 49.4) |
45.9 (38.7, 53.2) |
| Any pain | 43.8 (37.2, 50.5) |
46.2 (41.3, 51.0) |
48.5 (45.2, 51.9) |
50.9 (47.9, 53.9) |
53.3 (49.3, 57.3) |
55.6 (49.9, 61.4) |
58.2 (50.4, 65.9) |
|
| Depression | 38.3 (32.6, 44.0) |
39.8 (35.4, 44.1) |
41.2 (37.7, 44.7) |
42.7 (39.2, 46.1) |
44.1 (39.9, 48.4) |
45.6 (39.9, 51.3) |
47.2 (39.8, 54.6) |
|
| Periodic confusion | 25.7 (20.2, 31.2) |
27.6 (23.2, 32.1) |
29.6 (26.2, 33.0) |
31.7 (28.8, 34.5) |
33.8 (30.7, 36.8) |
36.0 (31.8, 40.1) |
38.4 (32.6, 44.2) |
|
| Dyspnea | 33.8 (28.6, 39.1) |
36.1 (31.8, 40.4) |
38.4 (34.8, 42.0) |
40.7 (37.4, 44.1) |
43.1 (39.4, 46.9) |
45.6 (40.9, 50.2) |
48.2 (42.2, 54.2) |
|
| Incontinence | 26.5 (19.7, 33.3) |
28.4 (23.0, 33.8) |
30.4 (26.4, 34.5) |
32.5 (29.4, 35.6) |
34.6 (31.4, 37.8) |
36.8 (32.4, 41.3) |
39.3 (32.9, 45.6) |
|
| Severe fatigue | 42.4 (36.5, 48.3) |
43.9 (39.6, 48.2) |
45.4 (42.3, 48.4) |
46.9 (44.1, 49.6) |
48.4 (44.6, 52.1) |
49.9 (44.5, 55.2) |
51.5 (44.2, 58.7) |
|
| Anorexia | 36.6 (31.3, 41.9) |
37.8 (33.8, 41.8) |
39.1 (35.8, 42.3) |
40.3 (36.8, 43.9) |
41.6 (36.9, 46.3) |
42.9 (36.6, 49.2) |
44.3 (36.1, 52.6) |
|
| Frequent vomiting | 4.9 (2.4, 7.3) |
5.5 (3.4, 7.6) |
6.2 (4.6, 7.8) |
7.0 (5.7, 8.3) |
7.8 (6.3, 9.4) |
8.8 (6.4, 11.3) |
10.0 (6.1, 13.9) |
|
a
Analysis accounts for complex survey design
b
Adjusted prevalence is predicted from regression models of each symptom on time of death, controlling for age at death, gender, race/ethnicity, and time elapsed between decedent's death and proxy's interview