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. 2015 Mar 2;11(3):e1004666. doi: 10.1371/journal.ppat.1004666

Fig 6. Schematic representation of regulation of amoebic actin dots.

Fig 6

The EhFNR bound to the fibronectin, turns on an intracellular signaling cascade. Rab21 acts downstream of the EhFNR, possibly by sensing the ligated form of the receptor, a function dependent on its nucleotide bound state. These signaling events finally lead to changes in the actin cytoskeleton of the pathogen. Collagen type I possibly act through the CRD region of the Hgl subunit of the Gal/GalNAc lectin complex and inhibits the amoebic actin dots.