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. Author manuscript; available in PMC: 2015 Mar 3.
Published in final edited form as: Top Curr Chem. 2013;337:189–208. doi: 10.1007/128_2012_412

Figure 1.

Figure 1

A ribbon diagram of a monomer of human heart lactate dehydrogenase demonstrating the promoting vibration. The donor and acceptor: the nicotinamide ring, and lactate are colored red. The promoting vibration residues, Val31, Gly32, Met33, Leu65, Gln66 (yellow) are compressed towards the active site bringing the NC4 of the nicotinamide ring and substrate carbon closer together while Arg106 (yellow) relaxes away locking the substrate in product formation. These residues span the entire length of the monomer to the edge of the protein. Reprinted with permission from J. Chem. Phys. B. 10.1021/jp207876k 2011