Table 2.
Accelerating rotarod performance and improvement compared with handling-induced convulsion severity in air- and ethanoltreated mice
| Strain | N (A) | N (E) | Performance (A) | Performance (E) | Withdrawal performance decrement |
Improvement (A) | Improvement (E) | Withdrawal improvement decrement |
|---|---|---|---|---|---|---|---|---|
| 129S1/SvImJ | 29 | 22 | 38.12 ±1.98 | 18.86 ±1.60 | 19.26 ± 1.60 | 25.24 ± 3.52 | 3.98± 1.67 | 21.25 ± 1.67 |
| A/J | 28 | 23 | 37.64 ±1.34 | 21.92 ±1.41 | 15.72± 1.41 | 9.26 ± 2.50 | − 1.49± 1.37 | 10.76± 1.37 |
| BALB/cByJ | 28 | 25 | 35.77 ±1.85 | 25.94 ±1.72 | 9.83 ± 1.72 | 15.12 ± 1.98 | 6.79± 1.47 | 8.33 ± 1.47 |
| C3H/HeJ | 26 | 16 | 35.69 ±1.48 | 26.67 ±1.18 | 9.02 ± 1.18 | 10.64± 2.49 | 4.41 ± 3.07 | 6.22 ± 3.07 |
| C57BL/6J | 26 | 24 | 51.87 ±2.70 | 38.01 ±2.02 | 13.86± 2.02 | 30.95 ± 4.18 | 21.99± 2.55 | 8.97± 2.55 |
| DBA/2J | 23 | 27 | 35.38 ±3.01 | 16.82 ±0.77 | 18.55 ± 0.77 | 11.61 ± 2.04 | − 0.47± 1.13 | 12.08± 1.13 |
| FVB/NJ | 30 | 23 | 28.21 ±1.80 | 18.14 ±1.46 | 10.07± 1.46 | 4.59± 1.43 | 1.77± 1.61 | 2.82 ± 1.61 |
| Strain | N (A) | N (E) | Δ Area 25** | |||||
| 129S1/SvImJ | 9 | 14 | 47.22 ±1.06 | |||||
| AKR | 8 | 8 | 53.19 ±9.60 | |||||
| BALB/cByJ | 8 | 6 | 31.25 ±2.21 | |||||
| C3H/HeJ | 9 | 9 | 59.67 ±7.19 | |||||
| C57BL/6J | 9 | 19 | 25.47 ±4.74 | |||||
| DBA/2J | 10 | 12 | 75.81 ±2.49 | |||||
| FVB/NJ. | 13 | 16 | 53.1 ±2.52 |
Upper half: Performance and improvement values are given as the mean ±standard error of the mean (s) and were defined in Data analysis section. Withdrawal performance and withdrawal improvement decrement indices were derived as described in the Data analysis section.
Lower half: Δ Area 25** = area under the 25-h handling-induced convulsion (HIC) curve for each strain expressed as a difference score for the strain mean control area 25 values (analogous to withdrawal decrement scores for rotarod variables above). Data are from Metten and Crabbe (2005).
A, air controls; E, ethanol-withdrawing mice.