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. Author manuscript; available in PMC: 2015 Mar 3.
Published in final edited form as: Exp Neurol. 2010 Dec 22;228(1):80–90. doi: 10.1016/j.expneurol.2010.12.011

Fig. 7.

Fig. 7

PER2 rhythm within the SCN did not appear to be disrupted even in aged BACHD mice. Mice were held in DD and wheel running activity measured to determine circadian phase. IHC was used to measure PER2 immunoreactivity in the SCN (n = 3-4 per group) of BACHD and WT controls. Tissue was collected in subjective day (CT 2) or subjective night (CT 14). (top panels) Photomicrographs of SCN tissue of each genotype in low (10X) and higher (40X) magnification. (bottom panel) Numbers of PER2 immuno-positive cells in the SCN varied as a function of time of day with highest count in early night. No differences were found between the genotypes. Tukey's post-hoc comparison, **P<0.01 (vs. CT2).