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. 2015 Feb 23;7:59–79. doi: 10.2147/BCTT.S43799

Table 2.

miRNA-related risk loci associated with BC

Gene locus SNP Comments Population Clinical observation Reference
MIR27A rs895919 *C Asians No risk association 141
Caucasians Protective
Jewish BRCA2 carriers Increased risk 142
rs895819 A/G pre-miRNA Caucasian Decreased risk 143
pre-miRNA Asians No risk association 144
Caucasians Decreased risk
pre-miRNA Chinese (young) Decreased risk 35
pre-miRNA Chinese Decreased risk 34
Asians No risk association 31
Caucasians No risk association
MIR34B cluster rs4938723 T/C African Americans Increased survival 145
MIR100 rs1834306 G/A African Americans No risk association 33
European Americans Decreased overall risk
MIR101-2 rs1053872 C/G Primary transcript Chinese Increased risk 38
rs462480 A/C Primary transcript Chinese Increased risk 38
MIR106B rs1527423 A/G African Americans No risk association 33
European Americans Increased overall risk
MIR122A rs17669 A/G African Americans Decreased risk of ER+ BC 33
European Americans No risk association
MIR146A rs2910164 G/C Italian Earlier age of onset 146
Caucasians No risk association 147
Chinese No risk association 83
Asians No risk association 38
Caucasians No risk association
Asians Decreased risk (C allele) 144
Asians No risk association 31
Caucasians No risk association
Chinese No risk association 36
MIR149 rs2292832 T/G Asians No risk association 38
Caucasians No risk association
Chinese No risk association 36
Asians No risk association 31
Caucasians No risk association
MIR185 rs2008591 C/T African Americans Reduced risk 145
rs887205 A/G African Americans Reduced risk 145
MIR196A-2 rs11614913 T/C Korean Survival of HER2+ cases 148
Italian and German No risk association 37
Asians Decreased risk 141
Caucasians No risk association
Brazilian Decreased risk 149
Caucasian Decreased risk 147
Chinese and Korean Decreased risk 32
Chinese Increased risk 36
Chinese Increased risk 83
African Americans No risk association 33
European Americans No risk association
Asians No risk association 31
Caucasians No risk association
MIR204 rs7861254 G African Americans Decreased risk of ER− BC 33
European Americans No risk association
MIR206 rs6920648 A/G African Americans Increased survival 145
MIR219 rs107822 G/A African Americans Increased risk of ER− BC 33
European Americans No risk association
MIR331 rs11107973 A/G African Americans No risk association 33
European Americans Increased overall risk
MIR373 rs12983273 T/C Asians No risk association 38
Caucasians No risk association
MIR423 rs6505162 A/C pre-miRNA Caucasian Reduced risk 150
Jewish BRCA2 carriers Later age of onset 142
Asians No risk association 38
Caucasians No risk association
MIR455 rs2060133 C/G African Americans No risk association 33
European Americans Decreased risk of ER+ BC
MIR487 rs1951032 G/A African Americans No risk association 33
European Americans Increased overall risk
MIR495 rs2281611 C/A African Americans No risk association 33
European Americans Increased risk of ER− BC
MIR499 rs3746444 A/G Chinese Increased risk 36
Asians Increased risk 151
Caucasians No risk association
Asians Increased risk 152
Caucasians No risk association
Chinese Increased risk 32
Caucasians No risk association 147
rs3746444 T/C Asians Increased risk 153
Caucasians No risk association
Asians Increased risk 31
Caucasians No risk association
Asians Decreased risk 141
Caucasians No risk association
MIR513A-2 rs2018562 A/G African Americans Increased overall risk 33
European Americans No risk association
MIR544 rs10144193 A/T African Americans No risk association 33
European Americans Increased overall risk
MIR548A-2 rs878175 A/G African Americans No risk association 33
European Americans Decreased risk of ER+ BC
MIR595 rs4909238 A/G African Americans Increased risk of ER− BC 33
European Americans No risk association
MIR605 rs2043556 *A Asians Decreased risk 141
Caucasians No risk association
MIR606 rs12266981 G/A African Americans Increased risk of ER+ 33
European Americans No risk association
MIR608 rs4919510 C/G African Americans No risk association 33
European Americans Decreased risk of ER− BC
MIR628 rs8041885 A/G African Americans Decreased risk of ER+ BC 33
European Americans No risk association
rs8041044 C/A African Americans Decreased risk of ER+ 33
European Americans No risk association
MIR659 rs5750504 T/A African Americans No risk association 33
European Americans Increased overall risk
MIR758 rs12586258 G/A African Americans Decreased overall risk 33
European Americans No risk association
rs7141987 A/G African Americans No risk association 33
European Americans Increased risk of ER− BC
ATF1 3′ UTR rs11169571 C/T miR-320 MRE Jewish BRCA2 carriers Increased risk 142
BMPR1B 3′ UTR rs1434536 C/T miR-125b MRE Caucasian Increased risk 43
BRCA1 3′ UTR rs799917 C/T miR-638 MRE Italian Increased risk 154
HPGD 3′ UTR rs8752 G/A miR-485-5p MRE Chinese Increased risk in ER+ 155
IGF-1R 3′ UTR rs28674628 A/G miR-515-5p MRE Jewish BRCA1 carriers Earlier age of onset 156
IL23R 3′ UTR rs10889677 A/C let-7 MRE Chinese Increased risk (A allele) 157
Earlier age of onset (C allele)
Decreased risk 158
IQGAP1 3′ UTR rs1042538 A/T miR-124 MRE Chinese Decreased risk 159
ITGB4 3′ UTR rs743554 A/G miR-34a MREpredicted Swedish Increased risk 160
Reduced survival
KRAS 3′ UTR rs61764370 T/G let-7 MRE Caucasian Increased frequency in BRCA1 40
carriers/no risk association
Increased risk of TNBC 39
RAD52 3′ UTR rs7963551 A/C let-7 MRE Chinese Decreased risk 42
RYR3 3′ UTR rs1044129 A/G miR-367 MRE Chinese Increased risk and poor survival 161
SET8 3′ UTR rs16917496 C/T miR-502 MRE Asian Earlier age of onset 162
TGFBR1 3′ UTR rs334348 A/G miR-628-5p MRE Italian Increased risk 154
TGFB1 Exonic rs1982073 C/T miR-187 MRE Italian Increased risk 154
XRCC1 Exonic rs1799782 T/C miR-138 MRE Italian Decreased risk 154
AGO4 rs7354931 C/A miRNA RISC-loading, African Americans Decreased overall risk 33
miRNA–RISC activity European Americans No risk association
rs16822342 A/G African Americans Decreased risk of ER+ BC 33
European Americans No risk association
rs3820276 G/C African Americans Increased risk of ER+ BC 33
European Americans No risk association
DGCR8 rs417309 G/A Pre-miRNA Chinese Increased risk 42
rs9606241 A/G processing African Americans No risk association 33
European Americans Increased risk of ER+ BC
PACT rs2059691 G/A miRNA–RISC activity African Americans No risk association 33
European Americans Increased overall risk
XPO5 rs11077 A/C Pre-miRNA African Americans Decreased risk of ER+ BC 33
nuclear export European Americans No risk association

Abbreviations: BC, breast cancer; ER, estrogen receptor; HER2, human EGF-like receptor 2; miRNA, microRNA; MRE, microRNA recognition element (ie, binding site); RISC, RNA-induced silencing complex; UTR, untranslated region.