Table 2.
Statistically meaningful changes in mean mRNA levels detected within 4 hours after PEMF treatment relative to untreated control cells
| HDF | HEK | HMNC | |
|---|---|---|---|
| Heme oxygenases | ↑HMOX1* | ↑HMOX1* | ↑HMOX1** |
| Cellular redox enzymes | ↑NOX1* | ↑NOX1 | |
| ↑CAT | ↑CAT | ||
| ↑GSR | ↑GSR | ||
| ↑PRDX6 | ↑PRDX6 | ↑PRDX6 | |
| ↑SOD3 | ↑SOD3 | ↑SOD3 | |
| Lipid metabolism enzymes | |||
| Prostaglandin synthesis enzymes | ↑PTGS2 | ||
| ↑PTGDS | ↑PTGDS | ||
| ↑PTGES* | ↑PTGES | ||
| ↑PTGIS | ↑PTGIS | ↑PTGIS | |
| Lipoxygenases | ↑ALOX12 | ↑ALOX12 | |
| ↑ALOX15 | ↑ALOX15 | ||
| Interleukins | ↑IL1B* | ↑IL1B | ↑IL1B |
| ↑IL5 | |||
| ↑IL6 | ↑IL6 | ||
| ↑IL10* | ↑IL10* | ||
| ↑IL12B | ↑IL12B | ||
| ↑IL20 | |||
| ↑IL21 | |||
Notes: P<0.05 or better were met in all cases; P<0.01 and greater denoted by asterisks (*P<0.01 and **P<0.001). An increase or decrease in relative mRNA levels is indicated by upward- and downward-facing arrows, respectively.
Abbreviations: HDF, human dermal fibroblasts; HEK, human epidermal keratinocytes; HMNC, human mononuclear cells; mRNA, messenger RNA; PEMF, pulsed electromagnetic field.