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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Cortex. 2014 Oct 16;64:55–67. doi: 10.1016/j.cortex.2014.10.002

Table 4. Anatomical correlates of happiness reactivity.

Volume loss in predominantly left hemisphere regions is associated with greater happiness behavior (whole-brain analysis) and greater cardiovascular reactivity (masked to the significant cluster found in the behavioral analysis) during the happy film in FTD when controlling for age, sex, CDR-SB, diagnosis, study wave, field strength, handedness, and total intracranial volume. Montreal Neurological Institute coordinates (x, y, z) given for maximum T-score for the cluster (cluster size > 70 mm3). Results are significant at praw<.005, uncorrected.

Anatomical Region Cluster
Volume
(mm3) 		x y z Maximum
T-score
Happiness behavior
 Left ventrolateral prefrontal cortex 41136* −22 62 −4 3.98
 Left orbitofrontal cortex †
 Left rostromedial prefrontal cortex †
 Left striatum †
 Left anterior insula †
 Right orbitofrontal cortex †
Physiological reactivity
 Inter-beat interval
  Left medial orbitofrontal cortex 800 −18 70 −6 3.26
  Right medial orbitofrontal cortex 600 12 72 −2 3.23
  Left superior frontal gyrus 536 −6 64 30 3.06
  Right rostromedial prefrontal cortex 112 6 64 8 3.24
  Left frontopolar cortex 88 −10 62 −22 2.79
 Systolic blood pressure
  Left frontopolar cortex 320 −26 64 −4 3.12
  Left anterior insula 72 −42 16 −8 3.23
 Diastolic blood pressure
  Left frontopolar cortex 104 −22 56 −20 2.79
  Left anterior insula 96 −42 16 −8 3.11
 Mean arterial pressure
  Left anterior insula 640 −42 16 −8 3.93
  Left rostromedial prefrontal cortex 184 −6 64 28 2.98
80 −22 66 10 3.05
*

denotes the cluster significant at pFWE < .05.

†

signifies that these regions were included in the cluster above.