Table 2. The meta-analysis results of association between Cyclooxygenase-2 polymorphisms and hepatocellular carcinoma risk.
SNPs | Contrast model | OR(95%CL) | PA | Test for heterogeneity | publication bias (Egger’s test) | ||
---|---|---|---|---|---|---|---|
I2 (%) | P | t | p | ||||
−1195G/A | |||||||
A vs G | 1.118(0.947–1.319) | 0.186 | 65.1 | 0.009 | 0.12 | 0.909 | |
GA vs GG | 1.558(1.055–2.303) | 0.026 | 72.5 | 0.001 | 1.31 | 0.247 | |
AA vs GG | 1.466(1.194–1.801) | 0.000 | 31.5 | 0.187 | −0.26 | 0.808 | |
GA+AA vs GG | 1.356(1.148–1.602) | 0.000 | 23.4 | 0.251 | 2.10 | 0.090 | |
GG+GA vs AA | 0.982(0.692–1.392) | 0.917 | 82.1 | 0.000 | 0.71 | 0.508 | |
+8473T/C | |||||||
C vs T | 0.986(0.863–1.126) | 0.833 | 0.0 | 0.682 | 0.02 | 0.989 | |
TC vs TT | 0.927(0.752–1.144) | 0.480 | 0.0 | 0.471 | −0.34 | 0.790 | |
TC+CC vs TT | 0.934(0.760–1.147) | 0.513 | 0.0 | 0.497 | −0.37 | 0.775 | |
TC+TT vs CC | 0.764(0.482–1.210) | 0.252 | 0.0 | 0.374 | - | - | |
−765G/C | |||||||
C vs G | 1.223(0.700–2.136) | 0.480 | 41.38 | 0.000 | −0.16 | 0.882 | |
GC vs GG | 1.323(0.764–2.290) | 0.317 | 85.2 | 0.000 | −0.67 | 0.549 | |
CC vs GG | 0.863(0.164–4.530) | 0.861 | 13.56 | 0.001 | −1.39 | 0.398 | |
GC+CC vs GG | 1.269(0.710–2.274) | 0.423 | 87.7 | 0.000 | −0.85 | 0.460 | |
GG+GC vs CC | 1.195(0.244–5.844) | 0.826 | 12.63 | 0.002 | 1.18 | 0.447 |