Skip to main content
. Author manuscript; available in PMC: 2015 Sep 12.
Published in final edited form as: Pediatr Res. 2014 Dec 18;77(3):455–462. doi: 10.1038/pr.2014.209

Figure 1.

Figure 1

Alterations in prostacyclin synthase (PGIS) protein levels and activity in pulmonary artery endothelial cells (PAEC) in persistent pulmonary hypertension of the newborn (PPHN). A: Levels of 6-Keto-PGF1α, a stable metabolite of PGI2, were decreased in PPHN (gray bar) at basal level and after ATP stimulation (n=12, p<0.05 from control PAEC) compared to control cells (filled bar). B:PGIS protein levels were decreased in PPHN (n=14, p<0.05). Representative western blots were shown with β-actin used as loading control. C:PGIS mRNA levels were not different between PPHN and control PAEC (n=7, p=0.12). D: PGIS nitration (N-PGIS) was higher in PPHN than control PAEC. (n=6, p<0.05).*Indicates p<0.05 compared to control PAEC.