Table 2.
Tarsal contact toxicity of isoxazol-3-yl dialkylcarbamates to G3 and Akron strain of An. gambiae.
| Compound | R | An. gambiae G3 aLC50 μg/mL (95% CI) | An. gambiae Akron aLC50 μg/mL (95% CI) | bRR |
|---|---|---|---|---|
| 15a | Me | 0 % @1,000 μg/mL | ND | - |
| 15b | c-Pr | 0 % @1,000 μg/mL | ND | - |
| 15c | i-Pr | 84 (30-124) | 116 (79-151) | 1.4 |
| 15d | c-Bu | 349 (266-456) | 392 (281-593) | 1.1 |
| 15e | s-Bu | 41 (28-58) | 58 (42-92) | 1.4 |
| 15f | c-pentyl | 60 % @ 1,000 μg/mL | ND | - |
| 15g | 2-pentyl | 234 (163-307) | 296 (210-381) | 1.3 |
| 15h | 3-pentyl | 70 % @ 1,000 μg/mL | ND | - |
| 15i | 3-heptyl | 0 % @ 1,000 μg/mL | ND | - |
| 15j | i-Bu | 253 (184-367) | 151 (112-211) | 0.6 |
| 15k | 2-methylbutyl | 30 % @ 1,000 μg/mL | ND | - |
| 15l | neo-pentyl | 0% @ 1,000 μg/mL | ND | - |
| 15m | 3-methylbutyl | 415 (306-582) | 429 (331-563) | 1.0 |
| 15n | CH2CH2-c-Pr | 191 (109-343) | 198 (119-321) | 1.0 |
| 15o | CH2CH2-c-Bu | 40 % @ 1,000 μg/mL | ND | |
| 15p | CH2CH2-c-C5H9 | 674 (575-715) | ND | - |
| 23g | 2-pentyl | 410 (304-590) | 574 (513-633) | 1.4 |
| 25g | 2-pentyl | 0% @ 1,000 μg/mL | ND | - |
| 26g | 2-pentyl | 10% @ 1,000 μg/mL | ND | - |
a
Mosquitoes were exposed (1 h) to dried filter papers previously treated with ethanolic solutions of carbamates; mortality was recorded after 24 h. LC50 values derive from the concentrations of inhibitor used to treat the paper. ND designates “not determined”; compounds that did not show significant toxicity to susceptible G3 strain (100% mortality at 1000 μg/mL) were generally not tested on the resistant Akron strain.
b
Resistance ratio (RR), defined by LC50 (Akron)/LC50 (G3).