Figure 4. Differential miRNA enrichment in cytosol and mitochondria.

Volcano plot of RT-qPCR array data displayed differential miRNA enrichment in cytosol and mitochondria. Each data point was plotted as the level of fold change (Log₂^{(Fold Change—Mito vs Cyto)}) on the X-axis and corresponding statistical level of significance (−log₁₀^{(p value)}) on the y-axis. Fold change=2^ ^{−(Ct_Mito − Ct_Cyto)}. Mitochondria-enriched miRNAs with a more than 2 fold change were colored in red; likewise, cytosol-enriched miRNAs that having a change more than 2 fold were colored in green. Data points above the red-dashed-line are statistically significant (p < 0.05). The numeric data set of this plot is provided in Suppl. File 2.