(A) Resting-state anticorrelations for the medial prefrontal cortex (MPFC) seed are reduced in older adults; (top row) for younger adults (left column), older adults (middle column), and younger > older adults (right column). Top row depicts results from all participants. Second row depicts results from groups matched for motion artifacts. Results thresholded at p < 0.05, FDR cluster corrected in top two rows. The third row shows the same analyses at a more liberal threshold (p = .05, unc), and reveals that age-related differences occur only in frontal regions even at this threshold. (B) Resting-state anticorrelation for younger (gray) and older (black) adults between MPFC and bilateral DLPFCs; only younger adults exhibited significant anticorrelations in left and right DLPFC.