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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Neurobiol Aging. 2014 Dec 11;36(3):1483–1495. doi: 10.1016/j.neurobiolaging.2014.12.003

Figure 6.

Figure 6

Cytokine gene expression measured in hippocampal microglial cell lysates isolated from young and aged rats that were treated in vivo with either vehicle or mifepristone and incubated ex vivo with escalating doses of LPS for 4 hr. (a) Mifepristone treatment significantly reduced IL-1β gene expression in cell lysates of aged rats at the 10ng/mL LPS dose (p<0.05). (b) Mifepristone treatment significantly reduced IL-6 gene expression in cell lysates at the 10ng/mL LPS dose (p<0.05). (c) Mifepristone treatment significantly reduced TNFα gene expression in cell lysates of aged rats at the 10ng/mL LPS dose (p<0.05). Error bars represent S.E.M. *p<0.05; **p<0.01.