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AICAR pretreatment minimized endothelial cell activation induced by CLP. A. CLP increased endothelial activation in kidney as demonstrated by immunohistochemistry staining of ICAM-1 (red) in kidney tissue, at 8 hours following CLP. Pharmacological activation of AMPK by AICAR given 24 hours before CLP minimized this upregulation. B. CLP also caused an increase in endothelial activation in liver, measured by ICAM-1 (red), which was minimized by AICAR pretreatment.
