Table 3.
Full list of genes included in the hsa-miR-219a-5p gene set (as analyzed by GSEA)
| Gene Name | Location | Rank in Gene List | Rank Metric Score | Running ES | HGNC Gene Name /Aliases | Experimental Evidence |
|---|---|---|---|---|---|---|
| KIAA0182 | 16q24.1 | 31 | 0.148 | 0.108 | GSE1; Gse1 coiled-coil protein | predicted |
| PKNOX1 | 21q22.3 | 48 | 0.140 | 0.215 | PBX/knotted 1 homeobox 1 | predicted |
| TRAF7 | 16p13.3 | 55 | 0.137 | 0.323 | TNF receptor-associated factor 7, E3 ubiquitin protein ligase | predicted |
| CBFA2T3 | 16q24 | 98 | 0.118 | 0.403 | core-binding factor, runt domain, alpha subunit 2; translocated to, 3 | predicted |
| EPHA4 | 2q36.3 | 179 | 0.102 | 0.456 | EPH receptor A4 | predicted |
| MKNK2 | 19p13.3 | 373 | 0.076 | 0.448 | MAP kinase interacting serine/threonine kinase 2 | starBase CLIP-seq |
| DDAH1 | 1p22 | 413 | 0.072 | 0.492 | dimethylargininedimethylaminohydrolase 1 | starBase CLIP-seq |
| ESR1 | 6q24-q27 | 416 | 0.072 | 0.549 | estrogen receptor 1 | Luciferase Reporter Assay [105] |
| AKAP13 | 15q24-q25 | 426 | 0.071 | 0.603 | A kinase (PRKA) anchor protein 13 | starBase CLIP-seq |
| PHACTR2 | 6q24.1 | 788 | 0.039 | 0.505 | phosphatase and actin regulator 2 | starBase CLIP-seq |
| SLC31A1 | 9q32 | 1028 | 0.022 | 0.438 | solute carrier family 31 (copper transporter), member 1 | starBase CLIP-seq |
| KBTBD8 | 3p14 | 1086 | 0.019 | 0.433 | kelch repeat and BTB (POZ) domain containing 8 | starBase CLIP-seq |
| ADD2 | 2p13.3 | 1148 | 0.016 | 0.423 | adducin 2 (beta) | predicted |
| ERGIC1 | 5q35.1 | 1223 | 0.011 | 0.406 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | starBase CLIP-seq |
| RBM24 | 6p22.3 | 1260 | 0.009 | 0.401 | RNA binding motif protein 24 | predicted |
| KIAA0240 | 6p21.1 | 1318 | 0.005 | 0.384 | GLTSCR1L; GLTSCR1-like | predicted |
| NEK6 | 9q33.3-q34.11 | 1451 | −0.003 | 0.339 | NIMA-related kinase 6 | starBase CLIP-seq |
| THRB | 3p24.2 | 1551 | −0.009 | 0.311 | thyroid hormone receptor, beta | starBase CLIP-seq |
| SCN5A | 3p21 | 1646 | −0.015 | 0.290 | sodium channel, voltage-gated, type V, alpha subunit | predicted |
| TGFBR2 | 3p22 | 1907 | −0.032 | 0.222 | transforming growth factor, beta receptor II (70/80kDa) | starBase CLIP-seq |
| FZD4 | 11q14-q21 | 2324 | −0.063 | 0.124 | frizzled class receptor 4 | predicted |
| SEMA4G | 10q24.31 | 2354 | −0.066 | 0.167 | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, semaphoring) 4G | predicted |
Genes contributing to the core enrichment of the predicted hsa-miR-219a-5p gene set (leading edge subset) are bold. HGNC = HUGO (HUman Genome Organization) Gene Nomenclature Committee. ES = enrichment score. The last column indicates whether target genes were predicted based on bioinformatic algorithms (labelled as “predicted”) or are experimentally validated, e.g. by the starBase [126, 127] prediction intersection tool using CLIP-Seq (cross-linking immunoprecipitation-high-throughput sequencing) data.