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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Neuropharmacology. 2015 Jan 14;92:80–89. doi: 10.1016/j.neuropharm.2015.01.002

Figure 2. Action potential firing in NAc shell D1DR- and D2DR-positive MSNs is not affected by PKC inhibition.

Figure 2

(A) Representative traces of action potentials elicited from the same D1DR- and D2DR-positive neuron in the NAc shell before and after PKC blockade. Responses to a current step of 60 pA above rheobase are shown in each cell. (B) The firing rate vs. input (f-I) curves illustrate minimal or no effect of PKC inhibition in D1DR-positive (left) or D2DR-positive (right) MSNs (n=5–7 cells from 2 animals). Insets, PKC blockade is likewise without effect on rheobase current in both cell types. PKCi, PKC inhibitor (chelerythrine (10 μM) or Ro 31-8220 (10 μM)).