Skip to main content
. 2015 Jan 15;7(1):66–78.

Figure 1.

Figure 1

Melatonin inhibited inflammation of acute pulpitis and pro-inflammatory cytokine levels in the serum. A, E. HE-staining of pulp from the SHAM group, AP group and 5 d of AP+M and AP+E groups. Dental pulp injury induced a 5 day period of inflammation. Compared with HE-staining of the pulp at 5 d of AP group or AP+E group, AP+M displayed a relatively low percentage of necrosis at 5 d (bar=50 μm; n=8). B, C. Increased pro-inflammatory cytokine levels and decreased melatonin in the serum were observed at different time points of the AP group. D. Abdominal injection of melatonin ameliorated the increased level of IL-1β, IL-18 and TNF-α in the serum of AP rats. SHAM: results in the SHAM group; AP-1: results in the AP group at 1 d; AP-3: results in the AP group at 3 d; AP-5: results in the AP group at 5 d; AP+M-5: results in the AP+M group at 5 d; AP+E-5: results in the AP+M group at 5 d. **P<0.01 vs. SHAM; n=8.