TABLE 1.

Unadjusted Direct Medical Costs for Venous Thromboembolism Case/Control Pairs by Time Period

Time Period	Case/Control Pairs (n)	Case ($)	Control ($)	Mean Difference ($)	Wilcoxon Signed Rank P-Value
Year before index	355
mean		35,410	28,543	6,867	p= 0.001
median		22,879	19,522	2,646
P25*		14,043	12,401	−7,558
P75*		42,473	34,189	16,568
Min		399	657	−197,842
Max		260,056	259,780	243,635
Index to 5 years	355
mean		57,887	28,397	29,490	p<0.001
median		31,991	14,889	12,109
P25		15,596	5,837	−3,086
P75		61,324	35,124	41,269
min		0	0	−194,958
max		1,060,138	214,112	1,045,370
Index to 3 months	355
mean		23,154	7,259	15,895	p<0.001
median		9,519	1,961	6,989
P25		5,325	354	2,051
P75		23,833	7,332	18,236
min		0	0	−93,610
max		442,015	122,358	429,062
3 to 6 months	306
mean		4,799	2,433	2,366	p<0.001
median		750	295	301
P25		213	33	−233
P75		2,666	1,553	1,848
min		0	0	−57,622
max		102,411	61,212	102,411
6 months to 1 year	285
mean		6,613	3,566	3,047	p<0.001
median		1,230	765	195
P25		336	154	−1,010
P75		5,437	2,703	2,878
min		0	0	−85,583
max		232,455	85,897	230,580
1 year to 2 years	266
mean		10,952	5,984	4,967	p=0.034
median		2,363	2,073	126
P25		793	675	−2,208
P75		8,148	5,823	5,783
min		0	0	−113,374
max		339,919	113,861	337,983
2 to 3 years	252
mean		9,633	6,570	3,063	p=0.134
median		2,779	1,764	302
P25		740	601	−2,479
P75		8,402	5,982	4,680
min		0	0	−88,668
max		174,796	92,861	173,974
3 to 4 years	237
mean		8,885	5,733	3,151	p=0.086
median		2,069	1,670	326
P25		673	438	−2,375
P75		6,299	6,018	3,929
min		0	0	−65,110
max		196,820	65,110	167,847
4 to 5 years	219
mean		6,990	5,192	1,798	p=0.312
median		1,691	1,485	109
P25		488	540	−1,971
P75		6,394	5,092	3,193
min		0	0	−59,635
max		87,086	59,635	87,086

^*25^th and 75^th interquartile range