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. Author manuscript; available in PMC: 2016 Apr 2.
Published in final edited form as: Toxicol Lett. 2015 Feb 7;234(1):30–39. doi: 10.1016/j.toxlet.2015.02.002

Fig. 2.

Fig. 2

IL-1 receptor antagonist attenuated the LPS exposure-induced less anxiety-like behavioral, as determined by the elevated plus-maze test, 16 days (P21) (A), 44 days (P49) (B), and 65 days (P70) (C) after the injection. The results are shown as the numbers of open arm or enclosed arm entries (left panel) and the percentage of time spent in open arms or enclosed arms (time spent in open arms or enclosed arms divided by the sum of time spent in either arm) (right panel). The results are expressed as the mean±SD of six animals in each group and analyzed by the two-way ANOVA, followed by the Student–Newman–Keuls test. *p < 0.05 represents significant difference for the LPS group as # compared with the saline group. p < 0.05 represents significant difference for the LPS + IL-1ra group as compared with the LPS group.