Table 1.

Pharmacologic properties of loop diuretics

Property	Furosemide	Torsemide	Bumetanide
Relative potency	1x	2x	40x
Bioavailability (%)	10 – 100	80 – 100	80 – 100
Oral:Intravenous dosing	2:1	1:1	1:1
Time to onset (min)	60	60	30 – 60
Oral peak serum concentration (hr)	1	1	1 – 2
Absorption affected by food	Yes	No	Yes
Average half-life (hr)	2	3.5	1 – 1.5
Duration of effect (hr)	6 – 8	6 – 16	4 – 6
Decreased kaliuresis	No	Yes	No

Abbreviations: hr: hour; min: minute