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. 2014 Dec 10;113(5):1598–1615. doi: 10.1152/jn.00566.2014

Fig. 2.

Fig. 2.

Spinal cord injury. A: contusion injury at L2 resulted in severe damage of the dorsal columns and gray matter, as shown by glial fibrillary acidic protein (GFAP) staining in coronal spinal cord tissue sections. Asterisk denotes lesion epicenter. B: intact spinal cord tissue from sham animal. C and D: biomechanical data provided by the Infinite Horizon (IH) impactor demonstrated no difference between vehicle (SCI + Veh)- and Rac1 inhibitor NSC23766-treated (SCI + anti-Rac) SCI groups. E: 6 wk after SCI (above injury), PKC-γ staining produced bilateral labeling of the dorsal corticospinal tract (dCST) and lamina I/II. F: at the lumbar level L5 (below injury), the absence of PKC-γ immunoreactivity in the dorsal column white matter tracts demonstrates significant disruption of the dCST. SCI did not affect PKC-γ staining in superficial laminae. Scale bars, 500 μm.