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. 2014 Dec 10;113(5):1598–1615. doi: 10.1152/jn.00566.2014

Fig. 8.

Fig. 8.

Disruption of Rac1-regulated dendritic spines reduces SCI-induced H-reflex hyperexcitability. Representative traces show the M and H responses from paired-pulse testing in SCI + Veh below the injury (A) and SCI + anti-Rac (B) treatment groups. C: quantification of the %H-reflex response demonstrates that the H-reflex response in SCI + Veh animals exhibited reduced RDD (also see Fig. 6). Rac1 inhibitor treatment in SCI animals reduced the %H-reflex at 100, 50, and 10 ms compared with SCI + Veh (*P < 0.05). D: there was no significant difference in the %M-wave between SCI + Veh and SCI + anti-Rac. E: treatment with Rac1 inhibitor in SCI animals decreased the H/M ratio compared with SCI + Veh, as demonstrated by a steeper downward trend line.