Table 1.
Top five GO categories of biological process enriched by genes either up- or downregulated in human skeletal muscle cells after 10 days of differentiation
| GO Identity | GO Term | Genes, n | P Value | FDR |
|---|---|---|---|---|
| Upregulated genes | ||||
| GO:0006941 | striated muscle contraction | 15 | 1.9 × 10−12 | 3.7 × 10−9 |
| GO:0006936 | muscle contraction | 23 | 1.3 × 10−11 | 1.4 × 10−8 |
| GO:0003012 | muscle system process | 23 | 8.8 × 10−11 | 5.9 × 10−8 |
| GO:0007517 | muscle organ development | 20 | 7.6 × 10−7 | 3.8 × 10−4 |
| GO:0014706 | striated muscle tissue development | 14 | 5.4 × 10−6 | 2.2 × 10−3 |
| Downregulated genes | ||||
| GO:0000279 | M phase | 56 | 1.8 × 10−27 | 4.3 × 10−24 |
| GO:0022403 | cell cycle phase | 60 | 1.2 × 10−25 | 1.4 × 10−22 |
| GO:0000087 | M phase of mitotic cell cycle | 43 | 4.0 × 10−23 | 3.2 × 10−20 |
| GO:0000280 | nuclear division | 42 | 1.7 × 10−22 | 1.0 × 10−19 |
| GO:0007067 | mitosis | 42 | 1.7 × 10−22 | 1.0 × 10−19 |
Enrichment analysis of differentiation-related genes annotated with Gene Ontology (GO) terms demonstrates involvement of multiple molecular pathways and biological processes. Number (n) of regulated genes (D10/D0) is reported. P values were derived using Fisher's exact test. False discovery rate (FDR) determined by Benjamini-Hochberg adjusted P value.