Table 1.

Ki67 nuclear labeling after 70% hepatectomy

Hours	30	36	48	72	36 (F)	48 (F)
f/f	12.1 ± 1.9	41.5 ± 2.6	48.2 ± 5.6	33.6 ± 4.5	15.6 ± 1.5	44.1 ± 3.4
Cre f/f	5.3 ± 1.3	30.7 ± 4.6	59.7 ± 3.4	31.5 ± 2.2	13.5 ± 2.5	47.0 ± 5.9
Ratio	2.28	1.35	0.81	0.93	1.16	0.94

Liver sections from groups of hepatocyte-specific EGFR wild-type (f/f) or knockout (Cre f/f) (N = 4–6) were analyzed for nuclear Ki67 staining by immunohistochemistry (% of total hepatocyte nuclei). Means and standard errors were calculated for sections obtained from mice euthanized at different times after hepatectomy, including female (F) mice. The only statistically significant difference between was for the livers of male mice at 30 h (P < 0.005). The 36 and 48 h means of male mice approached statistical significance (P = 0.1140 and P = 0.08, respectively). The ratios of the means (ff/cre ff) are shown in the bottom row.