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Characterization of synapsin-loxp-hACE2 (SL) transgenic mice. A: schematic of the human (h) angiotensin-converting enzyme type 2 (ACE2) transgene flanked by LoxP sites and driven by a rat synapsin promoter. B: ACE2 activity assay showing that SL mice present significantly higher enzyme activity in the brain compared with nontransgenic (NT) mice. C: baseline mean arterial blood pressure (MAP) was not different in SL mice compared with NT mice.
