Effects of saturated fatty acids on the expression profile Bmal1, Per2, and Rev-erbα in mHypoE-37 neuronal cells. Relative mRNA transcript levels of Bmal1, Per2, and Rev-erbα, respectively, are shown. Bmal1 transcript levels are upregulated in the palmitate-treated cells compared with controls. *P < 0.05 between palmitate and control group at the indicated time point as determined by two-way ANOVA with post hoc t-test. Values are plotted as mean values ± SE. From Greco JA et al. (32).