Fig. 5.
Respiratory system elastance (elastanceRS) is less in Eln+/− than in Eln+/+ neonatal mice. Shown are in vivo measurements of lung inflation pressures in response to serial increases of tidal volume (μl/g body wt) delivered via tracheotomy in 6-day-old Eln+/+ (●) and Eln+/− (□) pups. Oblique lines are linear regression plots of elastanceRS [Δpressure (P)/Δvolume (V) = 1/complianceRS] for Eln+/+ mice (solid line, n = 6, R2 = 0.899) and for Eln+/− mice (broken line, n = 4, R2 = 0.900). ElastanceRS: Eln+/+ 1.44 ± 0.13; Eln+/− 1.14 ± 0.12 cmH2O·μl−1·g body wt−1. *Significant difference, Eln+/+ vs. Eln+/− groups, P < 0.01.