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. 2014 Dec 24;308(5):L464–L478. doi: 10.1152/ajplung.00278.2014

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Fig. 7. — Serine elastase activity increased in the lungs of Eln^+/+ mice (A), but did not change in Eln^+/− mice (B) after 8 h of MV. Urinary desmosine excretion increased in Eln^+/+ pups (C) but did not change in Eln^+/− pups (D) after MV for 24 h. E: Hart's-stained lung tissue sections (×400; scale bars = 100 μm) showing dispersion of elastic fibers (arrows, brown stain) in alveolar walls of both Eln^+/+ and Eln^+/− mice after 24 h of MV. F: while the distribution pattern of elastin was similar in the lungs of Eln^+/+ and Eln^+/− pups after MV, quantitative image analysis of lung tissue sections showed less elastin surface density in Eln^+/− mice than in Eln^+/+ mice. Summary data, means ± SD; n = 4/group; *significant difference, P < 0.05.