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. 2014 Dec 24;308(5):L429–L442. doi: 10.1152/ajplung.00285.2014

Fig. 4.

Fig. 4.

Increased oxidation of Trx in lungs of dnTrx-Tg mice: the redox state of Trx was determined as described in materials and methods. A. reduction and oxidation of hTrx in vitro using DTT or H2O2. B: redox state of hTrx in Trx-Tg and dnTrx-Tg mice lung in normoxia and hyperoxia. C: total Trx redox (mouse + overexpressed hTrx, both WT and mutant) state in the lungs of WT, Trx-Tg, and dnTrx-Tg mice. The top band is the noncarboxymethylated oxidized/mutated Trx, and the bottom band is the carboxymethylated reduced Trx.