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p53 expression increases in lungs of dnTrx-Tg mice in normoxia and decreases in lungs of Trx-Tg mice exposed to hyperoxia. A: Western analysis of p53 in WT or Trx-Tg mice. B: densitometry of A. C: Western analysis of p53 in lung tissue of WT or dnTrx-Tg mice. D: densitometry of C. *Significantly decreased in lungs of Trx-Tg mice in hyperoxia (P = 0.0001). **Significantly higher than WT mice exposed to 21% oxygen (ANOVA, Tukey's test, P = 0.0001).
