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. 2014 Dec 24;308(5):L429–L442. doi: 10.1152/ajplung.00285.2014

Fig. 9.

Fig. 9.

Increase apoptosis of lung cells occurs in the recovery period following hyperoxia, but not during the exposure period. Mice were exposed to 21% (room air) or 90% oxygen for 3 days; some were allowed a 3-day recovery. A: expression of cleaved caspase-3, cleaved poly(ADP-ribose) polymerase (PARP), Bax, Bcl2, PCNA, Trx, and α-tubulin was determined using western analysis. B: expression of pERK/ERK, pJNK/JNK, pASK, thioredoxin-interacting protein (TXNIP), and NADPH oxidase 4 (Nox4) during normoxia or hyperoxia in WT, dnTrx-Tg, and Trx-Tg lung in Western analysis.