Table 4. Relationship Between TTF-1 Expression and Clinicopathological Parameters in Lung Adenocarcinoma.
| TTF-1 Expression | ||||
|---|---|---|---|---|
| Clinicopathological Parameters | Total | Positive (n = 161) | Negative (n = 37) | P Value |
| Age, y | ||||
| <65 y | 109 | 92 (84.4) | 17 (15.6) | 0.2170 |
| ≥65 y | 89 | 69 (77.5) | 20 (22.5) | |
| Gender | ||||
| Male | 108 | 83 (76.9) | 25 (23.1) | 0.0777 |
| Female | 90 | 78 (86.7) | 12 (13.3) | |
| Smoking habit | ||||
| No | 93 | 84 (90.3) | 9 (9.7) | 0.0025 |
| Yes | 105 | 77 (73.3) | 28 (26.7) | |
| Tumor size | ||||
| ≤5 cm | 181 | 154 (85.1) | 27 (14.9) | <0.0001 |
| >5 cm | 17 | 7 (41.2) | 10 (58.8) | |
| Tumor differentiation | ||||
| Well/moderately | 168 | 143 (85.1) | 25 (14.9) | 0.0011 |
| Poorly | 30 | 18 (60.0) | 12 (30.0) | |
| p-TNM stage* | ||||
| Stage I | 130 | 113 (86.9) | 17 (13.1) | 0.0051 |
| Stage II/III | 68 | 48 (70.6) | 20 (29.4) | |
| Nodal status | ||||
| N0 | 152 | 121 (79.6) | 31 (20.4) | 0.2624 |
| N1/N2/N3 | 46 | 40 (87.0) | 6 (13.0) | |
| Vascular invasion | ||||
| No | 106 | 89 (84.0) | 17 (16.0) | 0.4715 |
| Yes | 69 | 55 (79.7) | 14 (20.3) | |
| Lymphatic invasion | ||||
| No | 101 | 83 (82.2) | 18 (17.8) | 0.5999 |
| Yes | 55 | 47 (85.5) | 8 (14.5) | |
| Pleural invasion | ||||
| No | 136 | 115 (84.6) | 21 (15.4) | 0.0827 |
| Yes | 62 | 46 (74.2) | 16 (25.8) | |
| Adjuvant chemotherapy | ||||
| No | 168 | 135 (80.4) | 33 (19.6) | 0.4141 |
| Yes | 30 | 26 (86.7) | 4 (13.3) | |
Data are presented as positive rate and average staining score. See Table 1 legend for expansion of abbreviations.
*Each case was reassigned for pathological stage according to the 7th edition of TNM classification[30, 31].