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. 2015 Jan 22;16(2):2294–2306. doi: 10.3390/ijms16022294

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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FBXW7 overexpression inhibits OS cell proliferation and induces apoptosis. (A) U2OS and MG-63 cells infected with empty vector (EV) and FBXW7 retroviruses were subjected to Western blot for FBXW7. n = 6; * p < 0.05 by t test; (B) Cell proliferation as measured by BrdU incorporation was inhibited by FBXW7 overexpression in U2OS and MG-63 cells compared with control cells. n = 3 repeats with similar results, * p < 0.05 by t test; (C) Cell cycle assay. The G1 phase fraction of FBXW7 overexpressing cells was increased compared with control cells. The S phase fraction of FBXW7 overexpressing cells was decreased compared with control cells. n = 3 repeats with similar results; * p < 0.05 by t test; and (D) Quantification of the apoptotic cell population by flow cytometry. FBXW7 overexpressing U2OS and MG-63 cells included a larger subset of apoptotic cells compared with control cells. n = 3 repeats with similar results; * p < 0.05 by t test.