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. 2015 Jan 22;16(2):2294–2306. doi: 10.3390/ijms16022294

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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FBXW7 overexpression suppresses tumor growth in a nude mouse xenograft model. (A) Empty vector (EV)- or FBXW7-expressing MG-63 cells were implanted into nude mice via subcutaneous injection. Tumor growth curves indicated that FBXW7 overexpression slowed down tumor growth in mice. n = 6, * p < 0.05 by two-way ANOVA. Scale bar: 1 cm; (B) The average percentage of Ki-67-positive cells in tumors arising from the FBXW7 group was significantly lower than those in the control group. n = 6, * p < 0.05 by t test. Scale bar: 50 μm; and (C) The average percentage of terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive cells in tumors isolated from FBXW7 group was significantly higher than those in control group. n = 6, * p < 0.05 by t test. Black arrows indicate positive cells in each photomicrograph.