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. 2015 Jan 22;16(2):2426–2445. doi: 10.3390/ijms16022426

Figure 5.

Figure 5

Effect of TPE on intratumor Nrf2 expression during DMBA-initiated breast carcinogenesis in rats. The animals were treated as indicated in legend to Figure 1. The mammary tumor sections were subjected to immunohistochemical analysis using anti-Nrf2 antibody. (A) Representative immunohistochemical localization of Nrf2 in nucleus. Arrows indicate immunohistochemical staining of Nrf2 (magnification: ×200). Various treatment groups are: (a) DMBA control; (b) TPE (50 mg/kg) plus DMBA; (c) TPE (100 mg/kg) plus DMBA; and (d) TPE (200 mg/kg) plus DMBA; (B) Quantification of nuclear Nrf2-immunopositive cells in rat mammary tumors induced by DMBA in the presence or absence of TPE treatment. Results are based on 1000 cells per animal and four animals per group. Each bar represents the mean ± SEM (n = 4). * p < 0.01 and ** p < 0.001 compared to DMBA control.