. 2015 Jan 26;16(2):2732–2746. doi: 10.3390/ijms16022732

Table 4.

Associations between haplotypes of three ADORA2A variants (rs4822489, rs2236624, rs2236625) and the risk of CHF.

Haplotypes ^a	CHF n (%)	Control n (%)	Without Adjustment		With Adjustment
Haplotypes ^a	CHF n (%)	Control n (%)	p ^b	OR (95% CI)	p ^c	OR (95% CI)
G-C-C	312.5 (52.06)	412.0 (51.89)	-	1.00	-	1.00
T-T-C	153.0 (25.76)	225.0 (28.34)	0.42	1.11 (0.87–1.42)	0.53	1.09 (0.84–1.42)
T-C-T	63.0 (10.61)	89.0 (11.21)	0.72	1.07 (0.75–1.53)	0.80	0.95 (0.65–1.39)
T-C-C	65.5 (11.03)	68.0 (8.56)	0.20	0.78 (0.54–1.14)	0.33	0.82 (0.54–1.22)

Bonferroni’s multiple adjustment was applied to the level of significance, which was set at p < 0.0125 (0.05/4). ^a SNPs of haplotype are (in sequence) rs4822489, rs2236624, and rs2236625. Frequency less than 0.05 will be ignored in analysis; ^b p values were calculated from two-sided chi-square tests or Fisher’s exact tests; ^c p values were calculated by unconditional logistic regression, adjusted for age, sex, and cardiovascular risk factors.