Table 5.
SNP genotype distribution and allele frequency, according to subsets, in CHF patients.
| Genotype | Hypertension n = 172 (%) | Dyslipidemia n = 84 (%) | Diabetes n = 104 (%) | Smoking Habit n = 90 (%) |
|---|---|---|---|---|
| rs2236624 | ||||
| TT | 14 (8.14) | 9 (10.71) | 12 (11.54) | 9 (10.00) |
| CT | 60 (34.88) | 34 (40.48) | 38 (35.54) | 33 (36.67) |
| CC | 98 (56.98) | 41 (48.81) | 54 (51.92) | 48 (53.33) |
| Allele frequency p-value | 0.743 a | 0.090 a | 0.130 a | 0.412 a |
| Genotype distribution p-value | 0.923 a | 0.239 a | 0.330 a | 0.735 a |
| rs2236625 | ||||
| CC | 139 (80.8) | 67 (79.76) | 86 (82.69) | 78 (86.67) |
| CT | 28 (16.28) | 16 (19.05) | 17 (16.35) | 12 (13.33) |
| TT | 5 (2.91) | 1 (1.19) | 1 (0.96) | 0 (0.00) |
| Allele frequency p-value | 0.993 a | 0.875 a | 0.278 a | 0.025 a |
| Genotype distribution p-value | 0.544 b | 0.965 b | 0.332 b | 0.047 b |
| rs4822489 | ||||
| TT | 36 (21.18) | 19 (22.62) | 25 (24.27) | 16 (18.18) |
| GT | 83 (48.82) | 48 (57.14) | 50 (48.54) | 53 (60.23) |
| GG | 51 (30.00) | 17 (20.24) | 28 (27.18) | 19 (21.59) |
| Allele frequency p-value | 0.287 a | 0.255 a | 0.704 a | 0.795 a |
| Genotype distribution p-value | 0.472 a | 0.206 a | 0.811 a | 0.094 a |
| rs5751876 | ||||
| TT | 40 (23.26) | 16 (19.05) | 18 (17.31) | 17 (18.89) |
| CT | 84 (48.84) | 43 (51.19) | 53 (50.96) | 46 (51.11) |
| CC | 48 (27.91) | 25 (29.76) | 33 (31.73) | 27 (30.00) |
| Allele frequency p-value | 0.561 a | 0.537 a | 0.166 a | 0.477 a |
| Genotype distribution p-value | 0.568 a | 0.470 a | 0.186 a | 0.424 a |
| rs7208480 | ||||
| CC | 77 (44.77) | 39 (46.43) | 50 (48.08) | 44 (48.89) |
| CT | 91 (52.91) | 43 (51.19) | 53 (50.96) | 44 (48.89) |
| TT | 4 (2.32) | 2 (2.38) | 1 (0.96) | 2 (2.22) |
| Allele frequency p-value | 0.992 a | 0.791 a | 0.360 a | 0.457 a |
| Genotype distribution p-value | 0.887 a | 0.950 a | 0.350 a | 0.683 a |
a χ2-test: allele frequency and genotype distribution among the three groups; b χ2-test: genotype distribution CC vs. CT + TT.