Table 6.
SNP genotype distribution and allele frequency, according to NYHA class, in CHF patients.
| Genotype | NYHA II | NYHA III | NYHA IV |
|---|---|---|---|
| rs2236624 | |||
| TT | 6 (2.01%) | 13 (4.35%) | 7 (2.34%) |
| CT | 41 (13.71%) | 38 (12.71%) | 25 (8.36%) |
| CC | 46 (15.38%) | 66 (22.07%) | 57 (19.06%) |
| Allele frequency p value | 0.307 a | ||
| Genotype distribution p value | 0.150 a | ||
| rs2236625 | |||
| CC | 67 (22.41%) | 98 (32.78%) | 73 (24.41%) |
| CT | 25 (8.36%) | 15 (5.02%) | 16 (5.35%) |
| TT | 1 (0.33%) | 4 (1.34%) | 0 |
| Allele frequency p value | 0.183 a | ||
| Genotype distribution p value | 0.089 b | ||
| rs4822489 | |||
| TT | 23 (7.74%) | 27 (9.09%) | 16 (5.39%) |
| GT | 51 (17.17%) | 62 (20.88%) | 37 (12.46%) |
| GG | 19 (6.40%) | 26 (8.75%) | 36 (12.12%) |
| Allele frequency p value | 0.020 a | ||
| Genotype distribution p value | 0.024 a | ||
| rs5751876 | |||
| TT | 24 (8.03%) | 29 (9.70%) | 17 (5.69%) |
| CT | 39 (13.04%) | 56 (18.73%) | 44 (14.72%) |
| CC | 30 (10.03%) | 32 (10.70%) | 28 (9.36%) |
| Allele frequency p value | 0.614 a | ||
| Genotype distribution p value | 0.708 a | ||
| rs7208480 | |||
| CC | 44 (14.72%) | 53 (17.73%) | 38 (12.71%) |
| CT | 46 (15.38%) | 63 (21.07%) | 47 (15.72%) |
| TT | 3 (1.00%) | 1 (0.33%) | 4 (1.34%) |
| Allele frequency p value | 0.753 a | ||
| Genotype distribution p value | 0.546 a | ||
Abbreviations: NYHA, New York Heart Association. a χ2-test: allele frequency and genotype distribution among the three groups; b χ2-test: genotype distribution CC vs. CT + TT.