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. 2015 Feb 3;16(2):3267–3282. doi: 10.3390/ijms16023267

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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EGFR inhibition improves antitumor efficacy when given in combination with AZD8055. (A) The tumor volumes from the same group mice were presented as mean ± SD. and statistically analyzed. *, p < 0.05 and **, p < 0.01 vs. AZD8055 treatment alone; (B) At necropsy, the representative xenografts were shown from the left to right with saline, AZD8055, erlotinib, AZD8055 and erlotinib combination; (C) the xenografts were lysed and subjected to western-blot for the presence of the indicated proteins in the xenograft tissues.

EGFR inhibition improves antitumor efficacy when given in combination with AZD8055. (A) The tumor volumes from the same group mice were presented as mean ± SD. and statistically analyzed. *, p < 0.05 and **, p < 0.01 vs. AZD8055 treatment alone; (B) At necropsy, the representative xenografts were shown from the left to right with saline, AZD8055, erlotinib, AZD8055 and erlotinib combination; (C) the xenografts were lysed and subjected to western-blot for the presence of the indicated proteins in the xenograft tissues.