. 2015 Feb 3;16(2):3307–3322. doi: 10.3390/ijms16023307

Table 3.

Association between HBV infection and Tregs.

Species or Model	Disease Status	Immune Subset	Frequency, Functions or Findings	References
Human	AHB Recovered	Isolated CD4⁺CD25⁺	Suppression of CD8⁺ cells	Franzese et al. [68]
	CHB		Frequecny (AHB = CHB = Healthy)
	Healhty subjects
Human	AHB Recovered	Isolated CD4⁺CD25⁺	Suppression of CD4⁺ cells	Stoop et al. [69]
	CH-B		Frequency(Chronic > recovered: Chronic > healthy donors)
	Healthy subjects
Human	AH-B	Isolated CD4⁺CD25⁺; FOXP3⁺ gated liver infiltrating lymphocytes	Suppression of CD4⁺ cells	Xu et al. [70]
	CH-B		Frequency(CH-B severe > CHB, CHB severe > AH-B, CH-B severe > healthy donors)
	Healthy subjects
Human	CH-B	Isolated CD4⁺ CD25⁺	Suppression of CD4⁺ cells	Kondo et al. [23]
	Healthy subjects		Chronic = healthy donors
Human	Treated CH-B	CD4⁺ CD25⁺ CTLA4⁺ CD45RO⁺ (FOXP3⁺)	Frequency (Treated CHB < CHB)	Stoop et al. [71]
	CH-B
	Healthy subjects
Human	Recovered AH-B	Isolated CD4⁺CD25⁺; FOXP3⁺ liver infiltrating lymphocytes	Suppression of CD4⁺ cells and CD8⁺ cells	Yang et al. [72]
	CH-B		Frequency(Chronic asymptomatic > chronic active > resolved = healthy controls)
	Healthy subjects
Human	CH-B	CD4⁺CD25⁺IL7R^-	sHSP60 enhances Tregs activity via TLR2 signaling	Kondo et al. [24]
	Treated CH-B patients		Frequency (Treated CHB < CHB)
	Healthy subjects
Woodchuck hepatits	Woodchuck hepatitis	CD4⁺FOXP3⁺	Frequency (WHV > Control)	Otano et al. [73]
HBV model			Interleukin-12 Increases Hepatic Tolerogenicity
Mouse	AdHBV	CD4⁺FOXP3⁺	Down-regulating the antiviral activity of effector T cells by limiting cytokine production and cytotoxicity	Stross et al. [74]
Human	HBV-HCC	CD4⁺CD25⁺FOXP3	TGF-b-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment	Yang et al. [75]
Human	CH-B	CD4⁺CD25⁺	Frequency (CH-B = Acute on choronic HBV = Healthy)	Dong et al. [76]
	Acute on choric HBV
	Healthy